Mathematical modeling of mutant transferrin-CRM107 molecular conjugates for cancer therapy

详细信息    查看全文

• 作者：Dennis J. Yoon^a ; Kevin Y. Chen^a ; André ; M. Lopes^a ; April A. Pan^a ; Joseph Shiloach^b ; Anne B. Mason^c ; Daniel T. Kamei^a ; ^{kamei@seas.ucla.edu}
• 关键词：Diphtheria toxin ; Drug delivery ; Targeted toxin
• 刊名：Journal of Theoretical Biology
• 出版年：2017
• 出版时间：7 March 2017
• 年：2017
• 卷：416
• 期：Complete
• 页码：88-98
• 全文大小：925 K
• 卷排序：416

文摘

Developed mathematical model of Tf-DT intracellular trafficking pathway. Used model to predict drug efficacy and selectivity of mutant Tf-CRM107 conjugates. Validated predictions with in vitro cytotoxicity experiments. Mutant Tf-CRM107 exhibits improved efficacy. Mutant Tf-CRM107 exhibits good therapeutic index for cancer therapy.