Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTa_N12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model

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• 作者：Rahul M. Nandre ; Qiangde Duan ; Yin Wang ; Weiping Zhang ; ^{wpzhang@vet.k-state.edu}
• 关键词：Toxoid fusion ; 3xSTaN12S-dmLT ; Enterotoxigenic Escherichia coli (ETEC) ; Diarrhea ; Vaccine ; Pig challenge model
• 刊名：Vaccine
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：35
• 期：4
• 页码：552-556
• 全文大小：460 K
• 卷排序：35

文摘

Toxoid fusion 3xSTaN12S-dmLT induces neutralizing antibodies in IM immunized pigs. Passive acquired antibodies protect piglets against STa ETEC diarrhea. A pig challenge mode is ideal for ETEC antitoxin vaccines.