Divide or Conquer: Cell Cycle Regulation of Invasive Behavior

详细信息    查看全文

• 作者：Abraham Q. Kohrman¹ ; David Q. Matus¹ ; ^@ ; ^{david.matus@stonybrook.edu}
• 关键词：cell cycle arrest ; cell invasion
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：12-25
• 全文大小：2807 K
• 卷排序：27

文摘

Cell invasion through the basement membrane (BM) occurs during normal embryonic development and is a fundamental feature of cancer metastasis. The underlying cellular and genetic machinery required for invasion has been difficult to identify, due to a lack of adequate in vivo models to accurately examine invasion in single cells at subcellular resolution. Recent evidence has documented a functional link between cell cycle arrest and invasive activity. While cancer progression is traditionally thought of as a disease of uncontrolled cell proliferation, cancer cell dissemination, a critical aspect of metastasis, may require a switch from a proliferative to an invasive state. In this work, we review evidence that BM invasion requires cell cycle arrest and discuss the implications of this concept with regard to limiting the lethality associated with cancer metastasis.