Anti-parathyroid treatment effectiveness and persistence in incident haemodialysis patients with secondary hyperparathyroidism

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• 作者：Angel Luis Martí ; n de Francisco^a ; ^{angelmartindefrancisco@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Iain Andrew Gillespie^b ; Ioanna Gioni^c ; Jü ; rgen Floege^d ; Florian Kronenberg^e ; Daniele Marcelli^f ; David Collins. Wheeler^g ; Marc Froissart^h ; Tilman Bernhard. Druekeⁱ ; on behalf of the ARO Steering Committee Cllaborators^&loz ;
• 关键词：Chronic kidney disease ; Chronic kidney disease-mineral and bone disorder ; Haemodialysis ; Secondary hyperparathyroidism ; Treatment initiation ; Treatment persistence ; Treatment discontinuation
• 刊名：Nefrología
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：36
• 期：2
• 页码：164-175
• 全文大小：1474 K

文摘

Anti-parathyroid treatment initiation and discontinuation are important decisions in chronic haemodialysis (HD) patients, where pill burden is often excessive. The present study aimed to describe secondary hyperparathyroidism (sHPT) drug therapy changes in HD patients.

Methods

Retrospective observational cohort study of incident European HD patients with sHPT who were prescribed calcitriol or alfacalcidol (alpha calcitriol), paricalcitol or cinacalcet.

Results

Treatment-naïve patients prescribed alpha calcitriol (N = 2259), paricalcitol (N = 1689) and cinacalcet (N = 1245) were considered for analysis. Serum intact parathyroid hormone (iPTH) levels decreased post-initiation with all treatment modalities; serum calcium and phosphate levels increased in response to activated vitamin D derivatives but decreased with cinacalcet. Approximately one-third of alpha calcitriol and paricalcitol patients but less than one-quarter of cinacalcet patients discontinued treatment. Although the three groups had comparable serum iPTH control at the time of treatment discontinuation, they differed in terms of calcium and phosphate levels. Following discontinuation, the evolution of laboratory parameters differed by treatment modality: whilst iPTH increased for all three treatment groups, calcium and phosphate decreased in patients who were being treated with alpha calcitriol and paricalcitol at the time of discontinuation, and increased in those who had been treated with cinacalcet.

Conclusions

In conditions of daily clinical practice, attaining and maintaining recommended biochemical control of sHPT appears to be more frequently achievable with cinacalcet than with activated vitamin D compounds.