Different forms of alpha-1 antitrypsin and neutrophil activation mediated by human anti-PR3 IgG antibodies
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- 作者：Marcin Surmiak ; Marek Sanak ; nfsanak@cyf-kr.edu.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：A1AT ; alpha 1 antitrypsin ; ANCA ; antineutrophil cytoplasmic antibodies ; CACNA1D ; calcium channel voltage-dependent l type alpha 1d subunit ; CACNB2 ; calcium channel voltage-dependent beta 2 subunit ; CCL2 ; chemokine (C-C motif) ligand 2 ; CXCL2 ; chemokine (C-X-C motif) ligand 2 ; FcγIIa ; Fcγ receptor IIa ; FcγIIIb ; Fcγ receptor IIIb ; FPLC ; Fast protein liquid chromatography ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; GPA ; granulomatosis with polyangiitis ; IgG ; immunoglobulin G ; IRAK1 ; interleuk
- 刊名：Pharmacological Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：68
- 期：6
- 页码：1276-1284
- 全文大小：1531 K
文摘
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Native alpha-1 antitrypsin can inhibit PR3/anti-PR3 interaction and genes activation/ROS production in cANCA stimulated granulocytes.
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Poor inhibition properties of polymerized A1AT are probably caused by loss of antiprotease activity by polymerized form of protein.
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Inhibition of cANCA mediated neutrophil activation by alpha-1 antitrypsin is connected with enzymatic activity of plasma expressed proteinase-3.