Cyclic AMP Recruits a Discrete Intracellular Ca²⁺ Store by Unmasking Hypersensitive IP₃ Receptors

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• 作者：Vera Konieczny¹ ; Stephen C. Tovey¹ ; Stefania Mataragka¹ ; David L. Prole¹ ; Colin W. Taylor¹ ; ² ; ^{cwt1000@cam.ac.uk}
• 关键词：cyclic AMP ; endoplasmic reticulum ; inositol 1 ; 4 ; 5-trisphosphate ; intracellular Ca2+ store ; IRBIT ; Golgi apparatus ; parathyroid hormone ; phospholipase C
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：711-722
• 全文大小：3303 K
• 卷排序：18

文摘

Cyclic AMP directly potentiates IP3-evoked Ca2+ release The Ca2+ stores released by IP3 alone or IP3 with cAMP are functionally independent Cyclic AMP unmasks high-affinity IP3 receptors in a discrete ER Ca2+ store Independent regulation of discrete Ca2+ stores increases signaling versatility