IFN-纬-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver
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- 作者：Henry W. Murraya ; hwmurray@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Marisa Mitchell-Flacka ; Gregory A. Taylorb ; c ; Xiaojing Mad ; e
- 关键词：Visceral leishmaniasis ; Leishmania donovani ; Irgm1 ; Irgm3
- 刊名：Experimental Parasitology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：157
- 期：Complete
- 页码：103-109
- 全文大小：2275 K
文摘
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IFN-纬 induces expression of immunity-related GTPases (IRG) in Leishmania donovani infection in the liver.
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In liver, both Irgm1 and Irgm3 promote early intracellular resistance and granuloma assembly.
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Irgm3, but not Irgm1, optimizes macrophage parasite killing induced by antimony chemotherapy.
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IFN-纬-induced IRGs exert regulatory antileishmanial effects.