Cyclometallated iridium phosphors with amino acid ancillary ligand for intracellular imaging

详细信息    查看全文

• 作者：Tian-Yi Li¹ ; Hua-Chao Chen¹ ; Yi-Ming Jing ; Hua-Bo Han ; Xiao Liang ; You-Xuan Zheng ; ^{yxzheng@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Wei-Jiang He ; ^{heweij69@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Iridium complex ; l-Alanine ; Water solubility ; Phosphorescent materials ; Cell imaging
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：27
• 期：10
• 页码：1582-1585
• 全文大小：834 K

文摘

Two new iridium complexes, (dfppy)₂Ir(l-alanine) (dfppy = 2-(2,4-difluorophenyl)pyridine) and (piq)₂Ir(l-alanine) (piq = 1-phenylisoquinoline) were prepared with l-alanine as ancillary ligand. The two complexes show bright greenish-blue and red emission respectively. Theoretic study demonstrated that the emission nature of these complexes is mainly determined by the main ligand. And their improved aqueous solubility and the retained quantum yield favor their application in cell imaging. Intracellular imaging suggested that these two complexes have fine cell membrane permeability and is mainly distributed in cytoplasm. This study displayed a new strategy to design aqueous soluble phosphorescent cyclometallated Ir(III) complex via introducing amino acid as ancillary ligand.