Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice

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• 作者：Prasenjit Manna ; Arunkumar E. Achari ; Sushil K. Jain ; ^{sjain@lsuhsc.edu}
• 关键词：High glucose ; Oxidative stress ; Vitamin D ; SIRT1/AMPK/IRS1/GLUT4 ; Glucose metabolism
• 刊名：Archives of Biochemistry and Biophysics
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：615
• 期：Complete
• 页码：22-34
• 全文大小：3401 K
• 卷排序：615

文摘

1,25(OH)2D3 improved glucose metabolism via SIRT-1/AMPK/GLUT-4 cascade. 1,25(OH)2D3 ameliorates HG induced oxidative stress through NOX4/Nrf2/Trx pathway. VDR signaling plays a key role in mediating the effect of 1,25(OH)2D3.