Towards the standardization of stem cell therapy studies for ischemic heart diseases: Bridging the gap between animal models and the clinical setting

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• 作者：Fá ; bio Trindade^a ; ^b ; ^{fabiotrindade@ua.pt} ; Adelino Leite-Moreira^b ; Joã ; o Ferreira-Martins^c ; Rita Ferreira^d ; Inê ; s Falcã ; o-Pires^b ; Rui Vitorino^a ; ^b ; ^{rvitorino@ua.pt}
• 关键词：Stem cell therapy ; Regenerative medicine ; Animal model ; Heart diseases
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：465-480
• 全文大小：1367 K
• 卷排序：228

文摘

Heart transplantation remains as the ultimate treatment for end-stage heart failure. Numerous and diverse stem cell therapies have failed to succeed in clinical trials. Protocol variations among labs should be reduced before planning new animal studies. A unifying flowchart is presented as a suggestion for future studies. Biofluid molecular monitoring should be included to evaluate therapeutic success.