Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns

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• 作者：Fumihiro Sugawa ; Yuka Wada ; Tetsuo Maruyama ; Hiroshi Uchida ; Bunpei Ishizuka ; Tsutomu Ogata
• 刊名：Fertility and Sterility
• 出版年：2009
• 出版时间：February 2009
• 年：2009
• 卷：91
• 期：2
• 页码：649-652
• 全文大小：170 K

文摘

The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.