Oxidative stress reflected by increased F₂-isoprostanes is associated with increasing urinary 11-dehydro thromboxane B₂ levels in patients with coronary artery disease

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• 作者：Peter A. McCullough ; MD ; MPH^a ; ^b ; ^c ; ^d ; ^e ; ^{peteramccullough@gmail.com} ; Anupama Vasudevan ; BDS ; MPH ; PhD^b ; ^e ; ^f ; ^{Anupama.Vasudevan@BSWHealth.org} ; Luis R. Lopez ; MD^g ; ^{LLopez@corgenix.com} ; Caren Swift ; RN ; BSN^f ; ^h ; ^{Caren.Swift@BSWHealth.org} ; Margarita Peterson^f ; ^h ; ^{mpeters@wakehealth.edu} ; Jeanna Bennett-Firmin^f ; ^h ; ^{Jeanna.bennettfirmin@bswhealth.org} ; Raphael Schiffmann ; MD ; MHSc^f ; ^h ; ^{Raphael.Schiffmann@BSWHealth.org} ; Teodoro Bottiglieri ; PhD^f ; ^h ; ^{Teodoro.Bottiglieri@BSWHealth.org}
• 刊名：Thrombosis Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：148
• 期：Complete
• 页码：85-88
• 全文大小：389 K
• 卷排序：148

文摘

Oxidative stress is a potential mechanism of incomplete inhibition of COX-1. 8-isoPGF2α was found to be independently and positively associated with 11dhTxB2. This suggests that enhanced oxidative stress may result in platelet hyperactivity.