Sulfur and strontium isotopic compositions of sulfides and sulfates of hydrothermal veins from the SE Afar Rift (Djibouti). Sulfur isotopic compositions of sulfides (mainly pyrite) vary from − 9.2 to + 6.6‰. Strontium compositions of mineralized veins fall between 0.7039 and 0.7079. The δ34S values of the sulfate (gypsum) range from − 0.8 to + 14.3‰. The 87Sr/86Sr values of the sulfate fall in the range of 0.70389 to 0.70639. Magmatic and saline fluids contributed to the hydrothermal system in the SE Afar Rift.