Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability

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• 作者：Ibtissem Ghouzali^a ; ^b ; ¹ ; Caroline Lemaitre^a ; ^b ; ^c ; ¹ ; Wafa Bahlouli^a ; ^b ; ¹ ; Sa&iuml ; da Azhar^a ; ^b ; Christine Bô ; le-Feysot^a ; ^b ; Mathieu Meleine^a ; ^b ; Philippe Ducrotté ; ^a ; ^b ; ^c ; Pierre Dé ; chelotte^a ; ^b ; ^d ; Mo&iuml ; se Coë ; ffier^a ; ^b ; ^d ; ^{moise.coeffier@univ-rouen.fr}
• 关键词：Water avoidance stress ; Post-inflammatory model ; Proteasome ; Intestinal permeability ; Glutamine
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3278-3288
• 全文大小：1345 K
• 卷排序：1861

文摘

Ubiquitin Proteasome System is altered in the colon mucosa of stressed mice. Ubiquitin Proteasome System is altered in the colon post-inflammatory mucosa. Targeting immunoproteasome by pharmacological or genetic approaches prevents intestinal hyperpermeability. Intestinal hyperpermeability is limited by glutamine.