Low-dimensional compounds containing bioactive ligands. Part VIII: DNA interaction, antimicrobial and antitumor activities of ionic 5,7-dihalo-8-quinolinolato palladium(II) complexes with K⁺ and Cs⁺ cations

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• 作者：Veronika Farkasová ; ^a ; Sayed Ali Drweesh^b ; Andrea Lü ; kö ; ová ; ^a ; Danica Sabolová ; ^c ; Ivana D. Radojević^d ; Ljiljana R. Čomić^d ; Sava M. Vasić^d ; Helena Paulí ; ková ; ^e ; Stanislav Fečko^e ; Tatiana Bala&scaron ; ková ; ^e ; Má ; ria Vilková ; ^f ; Já ; n Imrich^f ; Ivan Potočňá ; k^a ; ^{ivan.potocnak@upjs.sk}
• 关键词：Quinolin-8-ol derivatives ; Pd(II) complexes ; Antimicrobial ; Antitumor ; DNA binding
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：80-88
• 全文大小：939 K
• 卷排序：167

文摘

Six new ionic Pd(II) complexes with halogen derivatives of quinolin-8-ol were prepared. Complexes interact with DNA by intercalative binding mode. Antimicrobial activity of complexes was tested against 19 strains of microorganisms. Antitumor properties were studied on three cancerous and non-cancerous cell lines. Complexes are selective cytotoxic against leukemic cell line L1210.