The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression

详细信息    查看全文

• 作者：Kevin Raehtz^a ; ^{kdr26@pitt.edu} ; Ivona Pandrea^a ; ^b ; ^{pandrea@pitt.edu} ; Cristian Apetrei^a ; ^c ; ^{apetreic@pitt.edu}
• 关键词：AGMs ; African green monkeys ; AIDS ; acquired immunodeficiency syndrome ; ART ; antiretroviral therapy ; GALT ; gut associated lymphatic tissue ; HIV ; human immunodeficiency virus ; LPS ; lipopolysaccharide ; MT ; microbial translocation ; MTIT ; mother-to-infant transmission ; NHPs ; nonhuman primates ; PTMs ; pig-tailed macaques ; RCM ; red-capped mangabeys ; RMs ; rhesus macaques ; SIV ; simian immunodeficiency virus ; SMs ; sooty mangabeys ; TCM ; central memory T cells ; Tregs ; regulatory T cells ; TSCM ; memory T-cells
• 刊名：Infection, Genetics and Evolution
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：Complete
• 页码：308-323
• 全文大小：842 K
• 卷排序：46

文摘

Over 40 species of African nonhuman primates carry species-specific SIVs SIV prevalence in the wild is very high in most of the natural host species SIV horizontal transmission is efficient in spite of low levels of mucosal target cells Maternal-to-infant transmission is rare in spite of massive offspring exposure to SIV Natural hosts of SIVs generally do not progress to AIDS Control of immune activation is the key factor behind lack of disease progression