文摘
Optically active 2-substituted-1-indanones or 2-substituted-1-tetralones are isolated from amino alcohol-mediated asymmetric domino reactions of 伪-disubstituted ketones, 尾-ketoesters, enol carbonates, 伪,尾-unsaturated ketones, a silyl enol ether, or a 尾-ketoacid, with some of these reactions occurring under UV-light irradiation or Pd catalysis. The absence of a relationship between the nature of the substrate and the absolute configuration of the ketone produced is due to the protonation of a common ammonium enolate as the key enantioselective step. The enantioselectivity depends on various factors, which indicates the occurrence of side pathways.