Silver nanoparticles suppresses brain-derived neurotrophic factor-induced cell survival in the human neuroblastoma cell line SH-SY5Y
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- 作者：Jung Hyun Park ; Sangiliyandi Gurunathan ; Yun-Jung Choi ; Jae Woong Han ; Hyuk Song ; Jin-Hoi Kim ; jhkim541@konkuk.ac.kr
- 关键词：Silver nanoparticles ; Brain-derived neurotrophic factor ; Cell viability ; Apoptosis ; Cellular signaling
- 刊名：Journal of Industrial and Engineering Chemistry
- 出版年：2017
- 出版时间：25 March 2017
- 年：2017
- 卷：47
- 期：Complete
- 页码：62-73
- 全文大小：4012 K
- 卷排序：47
文摘
Silver nanoparticles (AgNPs) are used as cytotoxic agents in various cancer cell lines; however, the cytotoxic effects of AgNPs on human neuroblastoma cells remain poorly understood. Here we report the mechanisms of action of AgNPs on brain-derived neurotrophic factor (BDNF) activation in human neuroblastoma cells using AgNPs. The results from biochemical, cellular and western blot analysis indicated that AgNPs significantly inhibit BDNF induced cell survival by enhanced leakage of lactate dehydrogenase, activation of reactive oxygen species, DNA damage, and modulation of various signaling molecules. Thus, AgNPs could serve as a potential candidate for developing novel therapeutic molecules for cancers.