Classification of anticancer drugs—a new system based on therapeutic targets

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• 作者：Enrique Espinosa ; Pilar Zamora ; Jaime Feliu ; Manuel Gonzá ; lez Baró ; n
• 关键词：Antineoplastic drugs ; chemotherapy ; classification ; monoclonal antibodies ; new drugs ; small molecules
• 刊名：Cancer Treatment Reviews
• 出版年：2003
• 出版时间：December 2003
• 年：2003
• 卷：29
• 期：6
• 页码：515-523
• 全文大小：138 K

文摘

The arrival of a great number of new antineoplastic agents has made it necessary to reclassify all of them. Anticancer drugs may act at different levels: cancer cells, endothelium, extracellular matrix, the immune system or host cells. The tumour cell can be targeted at the DNA, RNA or protein level. Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small molecules are directed against proteins. The endothelium and extracellular matrix may be affected also by specific antibodies and small molecules.