Telomeric Overhang Length Determines Structural Dynamics and Accessibility to Telomerase and ALT-Associated Proteins
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- 作者：Helen Hwang1 ; 2 ; Alex Kreig1 ; Jacob Calvert1 ; Justin Lormand3 ; Yongho Kwon4 ; James M. Daley4 ; Patrick Sung4 ; Patricia L. Opresko3 ; Sua Myong1 ; 5 ; 6 ; smyong@illinois.edu" class="auth_mail
- 刊名：Structure
- 出版年：10 June 2014
- 年：2014
- 卷：22
- 期：6
- 页码：842-853
- 全文大小：1433 K
文摘
- istitem" id="list_ulist0010">
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id="p0010">Telomeric overhang exhibits dynamic behavior when greater than four TTAGGG repeats
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id="p0015">Four and eight repeats yield low accessibility to WRN, BLM, Rad51, and telomerase
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id="p0020">Five to seven repeats yield increased accessibility to loading of the same proteins
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id="p0025">POT1 binds all repeat lengths proficiently, suggesting an active disruption of GQ