Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst
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- 作者：Shahab Mortezaei ; Noelle R. Catarineu ; James W. Canary
- 关键词：Asymmetric catalysis ; Ambidextrous ; Dynamic ; Helical inversion ; Michael addition
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：57
- 期：4
- 页码：459-462
- 全文大小：618 K
文摘
We provide proof-of-principle that an ambidextrous catalyst is capable of independent, dial-in control of the absolute stereochemistry of two similar nitrostyrene Michael addition reactions by in situ oxidation and reduction of the catalyst. The catalyst is capable of both static and dynamic catalysis modes; in combination both modes allow access to all four possible stereochemical outcomes for the two nitroalkane products in a single process.