mir-24 activity propagates stress-induced senescence by down regulating DNA topoisomerase 1

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• 作者：Huajie Bu^a ; Giorgia Baraldo^a ; G&uuml ; nter Lepperdinger^a ; ^b ; Pidder Jansen-D&uuml ; rr^a ; ^{pidder.jansen-duerr@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cellular senescence ; Oxidative stress ; miRNA ; mir-24 ; TOP1
• 刊名：Experimental Gerontology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：75
• 期：Complete
• 页码：48-52
• 全文大小：807 K

文摘

<dl class="listitem" id="list_l0005"><dt class="label">•dt><dd>

d="p0005">Mir-24 potentiates stress-induced senescence of human fibroblasts.

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d="p0010">DNA topoisomerase 1 (TOP1) is a functional target of mir-24.

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d="p0015">Downregulation of TOP1 expression enhances premature senescence in stress-exposed cells.

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