Rapid immune recovery and low TRM in haploidentical stem cell transplantation in children and adolescence using CD3/CD19-depleted stem cells

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• 作者：Peter  ; Bader MD ; Professor^a ;   ; ^{peter.bader@kgu.de} ; Jan  ; Soerensen^a ; Andrea  ; Jarisch MD^a ; Eva  ; Ponstingl MD^a ; Thomas  ; Krenn^c ;   ; ; Jö ; rg  ; Faber MD^d ; Matthias  ; Dü ; rken MD^e ; Harald  ; Reinhardt MD^f ; Andre  ; Willasch MD^a ; Ruth  ; Esser MD^a ; Halvard  ; Bö ; nig^b ; Ulrike  ; Koehl MD^a ; Thomas  ; Klingebiel MD ; Professor^a ;   ; ^{Thomas.klingebiel@kgu.de}
• 关键词：haploidentical stem cell transplantation ; immunotherapy ; leukemia ; malignant and non-malignant diseases
• 刊名：Best Practice Research Clinical Haematology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：24
• 期：3
• 页码：331-337
• 全文大小：332 K

文摘

Allogeneic stem cell transplantation has become an important option in the curative treatment of many patients with malignant and non-malignant systemic diseases. Non-availability of HLA identical donors can limit access to this life-saving treatment, especially in ethnic minority patients, for whom identical donors are often not available []. For many years, a central aim has been the development of stem cell transplantation across the HLA barrier and the use of haploidentical parents as stem cell donors. Such an approach will allow allogeneic transplantation of all patients in need. During the past years, it has become possible to optimize in?vitro graft manipulation procedures making this transplant procedure safer and more efficient. Therefore this haploidentical transplantation procedure can now serve as a basis for further cellular immunotherapy in the treatment of malignant and non-malignant diseases.