Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

详细信息    查看全文

• 作者：Justin G. Julander^a ; ^{justin.julander@usu.edu} ; Venkatraman Siddharthan^a ; Joe Evans^a ; Ray Taylor^b ; Kelsey Tolbert^a ; Chad Apuli^c ; Jason Stewart^a ; Preston Collins^a ; Makda Gebre^a ; Skot Neilson^a ; Arnaud Van Wettere^d ; Young-Min Lee^d ; William P. Sheridan^b ; John D. Morrey^a ; Y.S. Babu^b
• 关键词：Zika virus ; ZIKV ; AG129 mice ; Antiviral ; BCX4430 ; Ribavirin ; Flavivirus
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：14-22
• 全文大小：2848 K
• 卷排序：137

文摘

Protective efficacy of BCX4430 in various cell lines and in a lethal mouse model, including therapeutic treatment. Treatment with BCX4430 doesn't preclude antibody response. Time-course detection of viral RNA and infectious virus in various tissues. Pathology in the brain and spinal cord of infected mice. Detection of persistent virus in the testis.