Anti-inflammatory effect of a methanolic extract of leaves of Dregea volubilis

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• 作者：Emdad Hossain ; Debjani Sarkar ; Anup Maiti ; Mitali Chatterjee ; Subhash C. M ; al ; Jayanta Kumar Gupta
• 关键词：Anti-inflammatory activity ; Carrageenan induced paw edema ; Dregea volubilis ; Nitric oxide
• 刊名：Journal of Ethnopharmacology
• 出版年：2010
• 出版时间：11 November 2010
• 年：2010
• 卷：132
• 期：2
• 页码：525-528
• 全文大小：160 K

文摘

Aim of study

The aim of this study was to establish the anti-inflammatory activity of the methanolic extract of Dregea volubilis leaves (MEDV) with its fractions and to delineate the possible mechanism of action for MEDV.

Materials and methods

The anti-inflammatory activities of MEDV along with its petroleum ether and chloroform fractions were evaluated in a carrageenan induced model of acute inflammation. The effect of MEDV on lipopolysaccharide induced production of nitric oxide (NO) in macrophages was also studied.

Results

MEDV (100, 200 and 400 mg/kg body weight) significantly reduced carrageenan induced paw edema; chloroform fraction was most potent (66 % , p < 0.001). MEDV was non-toxic up to 125 μg/ml in mouse peritoneal macrophages wherein it (0–100 μg/ml) reduced lipopolysaccharide induced NO production.

Conclusion

MEDV possesses significant anti-inflammatory activity. Chloroform fraction of MEDV showed best anti-inflammatory activity.