Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice
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- 作者：Jinhwan Lima ; Laura Ortiza ; Brooke N. Nakamuraa ; Yvonne D. Hoanga ; Jesus Banuelosa ; Victoria N. Floresa ; Jefferson Y. Chanc ; Ulrike Luderera ; b ; uluderer@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NRF2 ; Ovarian aging ; Benzo[a]pyrene ; Oxidative stress ; Polycyclic aromatic hydrocarbon ; DNA adduct
- 刊名：Reproductive Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：58
- 期：Complete
- 页码：24-32
- 全文大小：2259 K
文摘
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The effects of deletion of Nrf2 on ovarian follicle dynamics were investigated.
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Nrf2 deletion alone caused accelerated age-related depletion of ovarian follicles.
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Nrf2 deletion did not modify follicle depletion by exposure to benzo[a]pyrene.