Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer
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- 作者：Yu Zhao1 ; 2 ; 3 ; 11 ; Liguo Wang4 ; 11 ; Shancheng Ren5 ; Lan Wang1 ; 2 ; 3 ; Patrick R. Blackburn1 ; Melissa S. McNulty1 ; Xu Gao5 ; Meng Qiao5 ; Robert L. Vessella6 ; Manish Kohli7 ; Jun Zhang8 ; R. Jeffrey Karnes2 ; Donald J. Tindall2 ; Youngsoo Kim9 ; Robert MacLeod9 ; Stephen C. Ekker1 ; Tiebang Kang10 ; Yinghao Sun5 ; sunyhsmmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Haojie Huang1 ; 2 ; 3 ; huang.haojie@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 April 2016
- 年：2016
- 卷：15
- 期：3
- 页码：599-610
- 全文大小：4197 K
文摘
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PSA eRNA is upregulated in CRPC cells in culture, PDXs, and patient tissues
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PSA eRNA binds to CYCLIN T1 and activates the P-TEFb complex
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PSA eRNA increases Pol II Ser2 phosphorylation
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A TAR-L motif in PSA eRNA is required for P-TEFb activation and CRPC growth