Development and evaluation of targeting ligands surface modified paclitaxel nanocrystals

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• 作者：Jeong Sun Sohn^a ; Doo-Soo Yoon^b ; Jun Youn Sohn^b ; Jeong-Sook Park^c ; ^{eicosa@cnu.ac.kr} ; Jin-Seok Choi^c ; ^{c34281@gmail.com}
• 关键词：PTX ; paclitaxel ; NC ; nanocrystals ; PTX-NC ; paclitaxel nanocrystals ; FE-SEM ; field emission scanning electron microscope ; DSC ; differential scanning calorimetry ; FT-IR ; Fourier transform infrared ; DW ; distilled water ; PBS ; phosphate buffered saline ; Tf ; apo-transferrin ; HA ; hyaluronic acid
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：228-237
• 全文大小：1352 K
• 卷排序：72

文摘

Surface modified PTX-NCs with HA and Tf are successfully prepared by adsorption method. Enhanced cellular uptake of modified PTX-NCs compared to unmodified PTX-NC Improved cell killing effect by surface modified PTX-NCs