Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon
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- 作者：Thang Van Nguyen1 ; J. Eugene Lee1 ; 2 ; Michael J. Sweredoski3 ; Seung-Joo Yang4 ; Seung-Je Jeon4 ; Joseph S. Harrison5 ; Jung-Hyuk Yim2 ; Sang Ghil Lee2 ; 6 ; Hiroshi Handa7 ; Brian Kuhlman5 ; Ji-Seon Jeong2 ; Justin M. Reitsma1 ; Chul-Seung Park4 ; Sonja Hess3 ; Raymond J. Deshaies1 ; 8 ; deshaies@caltech.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 March 2016
- 年：2016
- 卷：61
- 期：6
- 页码：809-820
- 全文大小：2618 K
文摘
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GS is an endogenous substrate of CRL4CRBN
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CRL4CRBN directly mediates the glutamine-induced degradation of GS
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Glutamine-stimulated acetylation of lysines 11 and 14 regulates GS degradation
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The thalidomide-binding domain of CRBN binds to an acetyllysine degron of GS