A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy

详细信息    查看全文

• 作者：Jione Kang ; Mi Gyeong Jeong ; Sera Oh ; Eun Jung Jang ; Hyo Kyeong Kim ; Eun Sook Hwang
• 关键词：Nerve injury ; MAFbx ; MuRF1 ; NRF2 ; FoxO1
• 刊名：FEBS Letters
• 出版年：3 January, 2014
• 年：2014
• 卷：588
• 期：1
• 页码：79-85
• 全文大小：2467 K

文摘

Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy.