Enhanced reactivity and enantioselectivity in catalytic glyoxylate-ene reactions using chiral bis(oxazoline)-copper complex in an ionic liquid

详细信息    查看全文

• 作者：Mina Kim ; Han Saem Jeong ; Chang-Eun Yeom ; B. Moon Kim
• 刊名：Tetrahedron: Asymmetry
• 出版年：2012
• 出版时间：15 July, 2012
• 年：2012
• 卷：23
• 期：13
• 页码：1019-1022
• 全文大小：431 K

文摘

An optimal hydrophobic ionic liquid was discovered as a solvent for highly enantioselective glyoxylate-ene reactions catalyzed by a chiral bis(oxazoline)-copper complex. The reactivity and stereoselectivity were highly dependent upon the property of the ionic liquids; reactions between olefins and ethyl glyoxylate in [Bmim]SbF₆ at ambient temperature provided remarkably enhanced reactivity and stereoselectivity, which greatly exceed those of the corresponding reactions in dichloromethane. Furthermore, the metal-ligand complex was readily recycled up to eight times while exhibiting no significant decrease in reaction efficiency.