- 作者：Jonathan J. Morrison ; Thomas J. Percival ; Nickolay P. Markov ; Carole Villamaria ; Daniel J. Scott ; Kaylyn A. Saches ; Jerry R. Spencer ; Todd E. Rasmussen
- 关键词：Hemorrhagic shock ; Vascular injury ; Pelvic bleeding ; Endovascular balloon
- 刊名：Journal of Surgical Research
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：177
- 期：2
- 页码：341-347
- 全文大小：420 K
ass=""h4"">Background
The objective of this study was to evaluate the efficacy of resuscitative endovascular aortic balloon occlusion (REBOA) of the distal aorta in a porcine model of pelvic hemorrhage.ass=""h4"">Methods
Swine were entered into three phases of study: injury (iliac artery), hemorrhage (45 s), and intervention (180 min). Three groups were studied: no intervention (NI, n = 7), a kaolin-impregnated gauze (Combat Gauze) (CG, n = 7), or REBOA (n = 7). The protocol was repeated with a dilutional coagulopathy (CG-C, n = 7, and REBOA-C, n = 7). Measures of physiology, rates of hemorrhage, and mortality were recorded.
ass=""h4"">Results
Rate of hemorrhage was greatest in the NI group, followed by the REBOA and CG groups (822 ¡À 415 mL/min versus 11 ¡À 13 and 0.2 ¡À 0.4 mL/min respectively; P < 0.001). MAP following intervention (at 15 min) was the same in the CG and REBOA groups and higher than in the NI group (70 ¡À 4 and 70 ¡À 11 mm Hg versus 5 ¡À 13 mm Hg respectively; P?<?0.001). There was 100 % mortality in the NI group, with no deaths in the CG or REBOA group. In the setting of coagulopathy, the rate of bleeding was higher in the CG-C versus the REBOA-C group (229 ¡À 295 mL/min versus 20 ¡À 7 mL/min, P = 0.085). MAP following intervention (15 min) was higher in the REBOA-C than the CG-C group (71 ¡À 12 mm Hg versus 28 ¡À 31 mm Hg; P = 0.005). There were 5 deaths (71.4 % ) in the CG-C group, but none in the REBOA-C group (P = 0.010).
ass=""h4"">Conclusion
Balloon occlusion of the aorta is an effective method to control pelvic arterial hemorrhage. This technique should be further developed as an adjunct to manage noncompressible pelvic hemorrhage.