A novel eight amino acid insertion contributes to the hemagglutinin cleavability and the virulence of a highly pathogenic avian influenza A (H7N3) virus in mice
详细信息 查看全文
- 作者：Xiangjie Sun ; Jessica A. Belser ; Terrence M. Tumpey ; tft9@cdc.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian influenza ; Influenza virus ; hemagglutinin
- 刊名：Virology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：488
- 期：Complete
- 页码：120-128
- 全文大小：1834 K
文摘
- •
An avian influenza H7N3 virus acquired a unique 8-amino acid (aa) insertion.
- •
The role of specific basic residues in the HA insertion in viral pathogenesis was determined.
- •
In mice, the 8-aa insertion is required for H7N3 virus virulence.
- •
The R residue at position P4 is essential for HA intracellular cleavage and virus virulence.