Stereoselective synthesis of the C21-C29 fragment of (+)-Sorangicin A employing iodocyclization reactions
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- 作者：Debendra K. Mohapatra<sup> ; sup><sup>mohapatra@iict.res.in" class="auth_mail" title="E-mail the corresponding authorsup> ; Shivalal Banoth ; Jhillu S. Yadav
- 关键词：Natural products ; Iodocyclization ; trans-2 ; 6-Disubstituted dihydropyran ; Isomerization ; Asymmetric 伪-aminoxylation of aldehyde
- 刊名：Tetrahedron Letters
- 出版年：2015
- 出版时间：21 October 2015
- 年：2015
- 卷：56
- 期：43
- 页码：5930-5932
- 全文大小：551 K
文摘
A stereoselective synthesis of the C21–C29 fragment of (+)-Sorangicin A has been described following our recently developed iodine-catalyzed tandem isomerization followed by C–O and C–C bond formation for the construction of trans-2,6-disubstituted dihydropyran as the key step. In this Letter, the problem of installing the C25 asymmetric center has been sorted out by utilizing an iodolactonization strategy.