Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish
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- 作者：Jiangfei Chenga ; b ; Suping Lva ; b ; Shangfei Niea ; b ; Jing Liua ; b ; Shoufang Tonga ; b ; Ning Kanga ; b ; Yanyan Xiaoa ; b ; Qiaoxiang Donga ; b ; Changjiang Huanga ; b ; cjhuang5711@163.com" class="auth_mail" title="E-mail the corresponding author ; Dongren Yanga ; b ; yangdongren@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zebrafish ; PFOS ; Chronic exposure ; Lipid metabolism
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：176
- 期：Complete
- 页码：45-52
- 全文大小：2990 K
文摘
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PFOS chronic exposure induces sex-dependent hepatic steotosis in zebrafish.
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PFOS interferes with β-oxidation, lipid synthesis, and lipid hepatic export process.
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Zebrafish could be used as an alternative model for PFOS chronic toxicity screening.