Microcalorimetry with correspondence analysis for studying the antibacterial effect of ephedrine on Escherichia coli

详细信息    查看全文

• 作者：Yanling Zhao^a ; ^{zhaoyl2855@126.com} ; Lei Jia^b ; Jiabo Wang^a ; Man Gong^c ; Ping Zhang^c ; Jianyu Li^c ; Honghong Liu^c ; Lifu Wang^c ; Yonggang Li^c ; Shijing Liu^c ; Xiaohe Xiao^a ; ^{xiaoxiaohe302@126.com}
• 关键词：Microcalorimetry ; Correspondence analysis ; Escherichia coli ; Ephedrine ; Antibacterial effect
• 刊名：Thermochimica Acta
• 出版年：2013
• 出版时间：10 April, 2013
• 年：2013
• 卷：557
• 期：Complete
• 页码：50-54
• 全文大小：511 K

文摘

The power-time curves of Escherichia coli growth at 37 ¡ãC affected by different concentrations of ephedrine were recorded by microcalorimetry. By analyzing some quantitative parameters from these curves using correspondence analysis, the effect of ephedrine on E. coli could be easily evaluated by analyzing the two main parameters, growth rate constant k₂ and maximum heat-output power P₂ of the second peak in the power-time curves. The results showed that the strong antibacterial effect of ephedrine on E. coli was concentration-depended: ephedrine at low concentration had poor inhibitory effect, and at high concentration notably inhibited the growth of E. coli. 376.8 ¦Ìg/ml of ephedrine could cause 50 % inhibition on E. coli. Ephedrine presented strong antibacterial effect on E. coli, which might be used as a potential novel antibacterial agent in practice. Microcalorimetric investigation of the effect of antibacterial agent on bacterial pathogens was promising in comparison to other methods.