The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo
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- 作者：Ruonan Bo ; Sisi Zheng ; Jie Xing ; Li Luo ; Yale Niu ; Yee Huang ; Zhenguang Liu ; Yuanliang Hu ; Jiaguo Liu ; Yi Wu ; Deyun Wang ; dywang@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LBPL ; Lycium barbarum polysaccharides liposome ; LBP ; Lycium barbarum polysaccharides ; BL ; blank liposome ; PCV2 ; porcine circovirus type 2 ; BC ; blank control ; PDI ; Polydispersity index ; PBS ; phosphate buffered saline ; IgG ; immunoglobulins G ; MTT ; 3-(4 ; 5-Dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; PHA ; Phytohemagglutinin ; LPS ; Lipopolysaccharide ; W/O ; oil adjuvant ; PI ; proliferation index
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：294-301
- 全文大小：2654 K
文摘
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The average diameters of liposomes (LBPL, BL) and liposome-formulated vaccines (LBPL-PCV2, BL-PCV2) were less than 200 nm and stable.
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LBPL could significantly promote splenocyte proliferation and the cytokine secretion of macrophages in vitro.
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LBPL as a vaccine adjuvant has good improvement effect on immune responses against PCV2 in vivo.
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