Exogenous BDNF increases neurogenesis in the hippocampus in experimental Streptococcus pneumoniae meningitis
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- 作者：Di Liana ; 1 ; Dake Hea ; 1 ; Jing Wua ; Ying Liub ; Mingjie Zhuc ; Jiaming Sunc ; Feng Chenb ; Ling Lia ; linglidoctor@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Streptococcus pneumoniae meningitis ; Brain-derived neurotrophic factor ; Neural stem cells ; Endogenous neurogenesis
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：294
- 期：Complete
- 页码：46-55
- 全文大小：2611 K
文摘
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Bacterial meningitis could activate proliferation of endogenous NSCs in hippocampus.
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Bacterial meningitis also impairs early differentiation of endogenous NSCs at the same time.
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Exogenous BDNF could improve neurogenesis of endogenous NSCs in the DG of hippocampus.
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BDNF treatment might be a promising therapy following bacterial meningitis.
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