Weight Loss, Inflammatory Markers, and Improvements of Iron Status in聽Overweight and Obese Children

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• 作者：Liya Gong ; MD¹ ; Feifei Yuan ; MD¹ ; Jianhua Teng ; MD¹ ; ² ; Xue Li ; MD¹ ; Sining Zheng ; MD¹ ; Liqun Lin ; MD¹ ; Haoyuan Deng ; MD¹ ; Guansheng Ma ; PhD³ ; Changhao Sun ; PhD¹ ; Ying Li ; PhD¹ ; ^{liying_helen@163.com" class="auth_mail}
• 关键词：BAZ ; Body mass index-for-age z-scores ; BF ; Body fat ; BMI ; Body mass index ; China CDC ; China Center for Disease Control and Prevention ; CRP ; C-reactive protein ; Hb ; Hemoglobin ; ID ; Iron deficiency ; IL-6 ; Interleukin-6 ; MET ; Metabolic equivalent task ; MLRM ; Multivariable linear regression model ; NISCOC ; Nutrition-based comprehensive intervention study on childhood obesity ; SF ; Serum ferritin ; sTfR ; Soluble transferrin receptor ; TF ; Transferrin ; WHO ; World Health Organization ; WHtr ; Waist-to-height
• 刊名：The Journal of Pediatrics
• 出版年：April, 2014
• 年：2014
• 卷：164
• 期：4
• 页码：795-800.e2
• 全文大小：456 K

文摘

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Objective

To assess the effect of a weight-loss program on improving iron status in overweight and obese school-aged children.

Study design

The data were analyzed in overweight and obese children (7-11 years of age; 114 girls and 212聽boys) with body mass index-for-age z-scores (BAZ) >1 from a weight-loss program. Schools were randomly divided into 2 groups: intervention and control. Children in the intervention group underwent a 1-year, nutrition-based comprehensive intervention weight-loss program. Anthropometric, dietary intake, and physical activity data were collected at baseline and follow-up (1 year). Iron status and inflammatory markers were assessed within a month.

Results

In the intervention group, BAZ decreased more than that in the control group (鈭?.4 卤 0.7 vs 鈭?.1 卤 0.6, P聽< .0001); and iron profiles and inflammation status were improved at follow-up. In multivariable linear regression models, a greater decrease of BAZ and inflammation factors predicted a better improvement of iron status. After adjustment of 螖BAZ, 螖C-reactive protein was significantly associated with 螖serum ferritin (尾: 1.89; 95% CI, 0.70-3.09; P = .002) and 螖soluble transferrin receptor (尾: 0.88; 95% CI, 0.16-0.59; P = .017); 螖interleukin-6 was significantly associated with 螖serum ferritin (尾: 1.22; 95% CI, 0.64-1.79; P < .0001).

Conclusions

Iron status and inflammation were improved by weight reduction. The improvement in inflammatory markers during weight reduction was independently associated with improvements of iron status.