Roles of L-type calcium channels (Ca_V1.2) and the distal C-terminus (DCT) in differentiation and mineralization of rat dental apical papilla stem cells (rSCAPs)

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• 作者：Qianqian Gao^a ; Jianping Ge^a ; Yanqin Ju^a ; Changsheng Li^a ; Jian Gao^a ; Meisheng Wu^a ; Shouliang Zhao^b ; ^{slzhao@fudan.edu.cn}
• 关键词：CaV1.2 ; voltage-gated calcium channels ; DCT ; distal C-terminus (DCT) of CaV1.2 ; rSCAPs ; rat dental apical papilla stem cells ; RT-PCR ; real-time PCR ; Ica ; inward Ca2+ currents ; HA/TCP ; hydroxyapatite/tricalcium phosphate ; DPSCs ; dental pulp stem cells ; shRNA ; short hairpin RNA ; SPF ; specific pathogen-free ; DCT-Flag ; DCT over-expressed vector ; CaV1.2-Sh ; CaV1.2 shRNA vector
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：74
• 期：Complete
• 页码：75-81
• 全文大小：2296 K
• 卷排序：74

文摘

The knockdown of CaV1.2 suppress rSCAPs differentiation. The expression of DCT inhibits rSCAPs differentiation. DCT is localized to the nucleus during the mineralization induction of rSCAPs.