A strategy for screening active lead compounds and functional compound combinations from herbal medicines based on pharmacophore filtering and knockout/knockin chromatography
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- 作者：Hui-Peng Song ; Si-Qi Wu ; Lian-Wen Qi ; Fang Long ; Li-Feng Jiang ; Ke Liu ; Hao Zeng ; Zhi-Meng Xu ; Ping Li ; liping2004@126.com" class="auth_mail" title="E-mail the corresponding author ; Hua Yang ; 104yang104@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Herbal medicine ; Quality control ; High-throughput screening ; Lead compound ; QTOF mass ; Knockout/knockin chromatography
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：1456
- 期：Complete
- 页码：176-186
- 全文大小：2478 K
文摘
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The pharmacophore-guided knockout/knockin chromatography was firstly established.
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A novel strategy was proposed to screen drug leads and filter useless compounds.
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A universal three-step method was developed to explain the function of herbs.
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Functional compound combination with five criteria was explicitly defined.
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The mechanisms of compounds in DQF against multiple free radicals were compared.