Expression of CDc6 after acute spinal cord injury in adult rats
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- 作者：Chen Chena ; 1 ; Jian Luc ; 1 ; Qin Yue ; Jian-Ru Xiaob ; Hai-Feng Weib ; Xin-jian Songc ; Jian-bing Gec ; Wei-dong Taoc ; Rong Qiana ; Xiao-Wei Yud ; njh306@163.com" class="auth_mail" title="E-mail the corresponding author ; Jian Zhaob ; drzhaojian123@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CDc6 ; Cell division cycle 6 ; SCI ; Spinal cord injury ; CNS ; Central nervous system ; PCNA ; Proliferating cell nuclear antigen ; NeuN ; Neuronal nuclear antigen ; GFAP ; Glial fibrillary acidic protein ; IBa1 ; Ionized calcium-binding adapter molecule 1 ; siRNA ; Short interfering RNA
- 刊名：Neuropeptides
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：59-67
- 全文大小：1950 K
文摘
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It is first time for us to find the role of CDc6 in spinal cord injury.
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CDc6 depletion by short interfering RNA inhibits astrocyte proliferation and reduces cyclin A and cyclin D1 protein levels.
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CDc6 knockdown also decreases neuronal apoptosis.