PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs

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• 作者：Zhexin Zhu¹ ; ⁶ ; Chunliang Li¹ ; ⁷ ; Yanwu Zeng² ; Jianyi Ding¹ ; ⁶ ; Zepeng Qu² ; Junjie Gu² ; Laixiang Ge² ; Fan Tang² ; Xin Huang¹ ; ⁶ ; Chenlin Zhou¹ ; Ping Wang³ ; Deyou Zheng³ ; ⁴ ; ⁵ ; Ying Jin¹ ; ² ; ⁸ ; ^{yjin@sibs.ac.cn}
• 关键词：PHB ; HIRA complexes ; H3.3 ; α-ketoglutarate ; human ESCs ; self-renewal ; epigenetics ; metabolism
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：20
• 期：2
• 页码：274-289.e7
• 全文大小：5916 K
• 卷排序：20

文摘

Genome-wide screening highlights PHB as a pluripotency/self-renewal factor in hESCs PHB interacts with histone H3.3 chaperone HIRA complexes PHB/HIRA complexes modulate genome-wide deposition of H3.3 at a range of promoters PHB and HIRA affect chromatin organization and expression of key metabolic genes