Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb.
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- 作者：Min Wang1 ; Xiao-bo Yang1 ; Jing-wen Zhao ; Chuan-jian Lu ; luchuanjian888@vip.sina.com" class="auth_mail" title="E-mail the corresponding author ; Wei Zhu ; zhuwei160409@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; zhuwei9201@163.com" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：Smilax glabra Roxb. ; Polysaccharide ; Structure ; Immunomodulatory activity ; NLRP3 inflammasome
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：390-402
- 全文大小：2796 K
文摘
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A novel heteropolysaccharide (SGRP1) with notable immunomudulatory activity is obtained from Smilax glabra Roxb.
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Structure of SGRP1 is characterized by HPGPC, GC, GC–MS, FT-IR and NMR.
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Immunomodulatory effects of SGRP1 are evaluated with RAW264.7 cells.
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SGRP1 promote the phagocytosis and increase the secretion of NO, IL-6, TNF-α and IL-1β.
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The immunomodularoty mechanism of SGRP1 is elucidated for the first time.
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