Apa2H1, the first head domain of Apa2 trimeric autotransporter adhesin, activates mouse bone marrow-derived dendritic cells and immunization with Apa2H1 protects against Actinobacillus pleuropneumoniae infection

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• 作者：Wanhai Qin^a ; ¹ ; ² ; Lei Wang^b ; ² ; Ruidong Zhai^a ; Qiuyue Ma^a ; Jianfang Liu^a ; Chuntong Bao^a ; Diangang Sun^a ; Hu Zhang^c ; Changjiang Sun^a ; Xin Feng^a ; Jingmin Gu^a ; Chongtao Du^a ; Wenyu Han^a ; P.R. Langford^d ; Liancheng Lei^a ; ^{leiliancheng@163.com}
• 关键词：Actinobacillus pleuropneumoniae ; Trimeric autotransporter adhesion ; Apa2H1 ; Vaccination ; Protection
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：108-117
• 全文大小：2779 K
• 卷排序：81

文摘

Apa2H1 is the head domain of Apa2 trimeric autotransporter adhesin. Apa2H1 activates mouse bone marrow-derived dendritic cells. Apa2H1 vaccination triggers a mixed Th1/Th2-type immune response. Immunization of Apa2H1 protects against Actinobacillus pleuropneumoniae infection.