Synergistic effects of negative-charged nanoparticles assisted by ultrasound on the reversal multidrug resistance phenotype in breast cancer cells
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- 作者：Dongxiao Wanga ; b ; 1 ; Wanxian Luoa ; 1 ; Ge Wenc ; Li Yangd ; Shaofu Honga ; Shiyu Zhanga ; Jianxin Diaoe ; Jianguo Wangb ; Hongqin Weia ; Yingjia Lia ; lyjia@smu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ying Wangb ; ningmengquan@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multidrug resistance ; Negative-charged nanoparticles ; Ultrasound ; Synergistic effects
- 刊名：Ultrasonics Sonochemistry
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：34
- 期：Complete
- 页码：448-457
- 全文大小：1878 K
文摘
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A negative-charged dual-ligand NP is synthesized but fails to overcome MDR.
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Cells treated with US prior to NP improves cytotoxity and eliminates damage from US.
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The strategy triggers endosomal escape and affects related proteins in MDR reversal.
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