Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations
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- 作者：David M. Roy1 ; 2 ; 8 ; Logan A. Walsh1 ; 8 ; Alexis Desrichard1 ; Jason T. Huse1 ; 3 ; 4 ; Wei Wu1 ; JianJiong Gao5 ; Promita Bose1 ; William Lee5 ; 6 ; Timothy A. Chan1 ; 3 ; 6 ; 7 ; chant@mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：9 May 2016
- 年：2016
- 卷：29
- 期：5
- 页码：737-750
- 全文大小：2668 K
文摘
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There exists a wide spectrum of arm-level SCNAs of variable prognostic “impact”
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Arm-level dissection via copy number status alone frequently yields false positives
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Only a minority of genetic loci influence powerful arm-level SCNA phenotypes
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Several 9p loci, but not CDKN2A, are linked to survival outcomes in LGG