Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels
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- 作者：Yumei Liua ; Haifeng Zoua ; Ping Zhaoa ; Bo Suna ; Jinghua Wanga ; Qingfei Konga ; Lili Mua ; Sihan Zhaoa ; Guangyou Wanga ; Dandan Wanga ; Yao Zhanga ; Jiaying Zhaoa ; Pengqi Yina ; Lei Liub ; Xiuli Zhaoc ; zxllili@163.com" class="auth_mail" title="E-mail the corresponding author ; Hulun Lia ; d ; lihl@hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：A2AR ; adenosine A2A receptor ; CFA ; complete Freund&rsquo ; s adjuvant ; CGS ; CGS21680 ; CRAC ; Ca2+ release-activated calcium ; EAE ; experimental autoimmune encephalomyelitis ; FITC ; fluorescein isothiocyanate ; MS ; multiple sclerosis ; PBS ; phosphate-buffered saline ; PE ; phycoerythrin ; SCH ; SCH58261
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：150-161
- 全文大小：4154 K
文摘
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The selective A2AR agonist, CGS21680 can inhibit the EAE progression.
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Treatment with CGS21680 significantly suppressed specific lymphocyte proliferation.
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Treatment with CGS21680 reduced infiltration of CD4+ T lymphocyte in nerve tissue.
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Treatment with CGS21680 reduced the expression of inflammatory cytokines.
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CGS21680 can increase the intracellular calcium concentration in lymphocytes.