CS/PAA@TPGS/PLGA nanoparticles with intracellular pH-sensitive sequential release for delivering drug to the nucleus of MDR cells
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- 作者：Ying-Ying Wanga ; Dan-Dan Zhanga ; Yan-Yan Konga ; Luan-Luan Shaoa ; Fen-Yi Zhanga ; b ; Yu Gaoa ; Xu Mua ; Jie Wanga ; Hao-Fan Lia ; Shu-Qin Yua ; yushuqin@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; shuqinyu@126.com" class="auth_mail" title="E-mail the corresponding author ; Qian Xuc ; q_xu68@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：pH-sensitive nanoparticles ; Intracellular sequential release ; Autophagy ; Endosome escape ; Nuclear drug delivery ; Multidrug resistance
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：716-727
- 全文大小：3803 K
文摘
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Synthesized a novel CS/PAA/VP-16@TPGS/PLGA NPs.
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The nanoparticles with characteristic of intracellular pH-sensitive sequential release.
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The nanoparticles delivery drug to nucleus of MDR cells.