Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering TLR4-MyD88-NFκB signaling cascades
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- 作者：Jin-Tao Liua ; b ; 1 ; jt_superliu@163.com" class="auth_mail" title="E-mail the corresponding author ; Bei-Yu Chenc ; 1 ; chenby@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jie-Qiong Zhangd ; zhangjieqiong1@163.com" class="auth_mail" title="E-mail the corresponding author ; Fang Kuanga ; KuangF@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liang-Wei Chena ; chenlw@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; lwchen@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BrdU ; bromodeoxyurinine ; DCX ; doublecortin ; DG ; dentate gyrus ; GFAP ; glial fibrillary acidic protein ; IL-1β ; interleukin-1β ; LPS ; lipopolysaccharide ; LTP ; long-term potentiation ; TLR4 ; toll-like receptor-4 ; TNFα ; tumor necrosis factor-alpha ; Pb ; plumbum ; PBS ; phosphate buffered saline
- 刊名：Toxicology Letters
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：239
- 期：2
- 页码：97-107
- 全文大小：4599 K
文摘
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In this study, we established a mouse model with lead (Pb) exposure.
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Lead exposure induced obvious microglial response, TLR4–MyD88–NFkB signaling activation, inflammatory cytokine generation and MAPK singling activation in the hippocampus.
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Increase of BrdU-incorporated cells and new-born astroglial cells, but no increase of DCX-labeled differentiated neuronal cells occurred in the dentate gyrus of hippocampus.
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Administration of MyD88 inhibitory peptide could relieve above Pb-induced effects.
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Data of this study suggested that lead exposure could induce microgliosis and astrogliogenesis in the hippocampal of young mice possibly by triggering TLR4–MyD88–NFkB signaling cascades.